We all know that some people age slower than others. Some men or women in their seventies look like they are in their fifties. Their skin is not as wrinkled, their brains are very active and their over-all appearance is one of youth.
In addition, these people live longer than their peers.
This anomaly has not been overlooked by medical researchers. Thousands of studies have been undertaken to determine why some people live to be a hundred with their faculties and appearance unimpaired; whilst other barely make it to sixty, looking like an octogenarian when they are fifty.
A number of hypothesis have come forward to explain this aberration from the norm.
The most popular hypothesis, supported by immense evidence from experiments with animals that age rapidly, is the CALORIC RESTRICTION HYPOTHESIS.
If we reduce the caloric content of an animal’s nutrition, whilst maintain the essential nutrients (vitamins, essential fatty acids, essential amino acids and sufficient water) we will invariably see these animals increase their longevity versus their control group and also maintain the characteristics of younger animals!
This experiment has been performed by respected scientists across the globe for several decades and their results are always similar. The explanations for these results are extremely varied and no one explanation has gained the acceptance or concurrence of most scientists.
MY SUGGESTED EXPLANATION
I do not pretend to be a research scientist, but in my reading of the research concerning Caloric Restriction and Longevity and Carcinogenesis I have noted that Growth Hormones, in particular, Insulin-like Growth Factor (IGF) SEEMS TO PLAY A ROLE IN AN INVERSE FASHION.
In other words, when we look at animals with lower levels of IGF we find that they live longer, look younger and have less cancer.
WHY SHOULD THIS BE? GROWTH HORMONE
There is absolutely no conflicting theories about the function of Growth Hormone in animal growth.
Growth hormone, secreted by the Pituitary Gland is absolutely essential for the maturation of any animal, including humans. When, for any reason, the pituitary gland does not secrete sufficient growth hormone, during their growing phase of an animal, the animal remains small with immature organs and appendages.
A very interesting side effect of Growth Hormone is that if an abnormally high level is secreted, the animal becomes larger than normal, which is expected; but, his secretions of IGF are also higher and his aging is faster and his lifespan shorter!
Tall humans, in general (not always) age more rapidly and die earlier than normal sized humans. And, their IGF levels are higher. We rarely see a Centenarian who is extremely tall.
IS THIS REALLY TRUE?
Here is an excerpt and a chart from a study on IGF levels:
Why is life expectancy increased when insulin-like growth factor 1 levels are reduced?
“Experimental results provide convincing evidence that in several experimental organisms, decreased insulin-like growth factor 1 (IGF1) signaling is associated with increased lifespan, even though in cell-culture systems reduced IGF1-receptor (IGF1R) activation increases the likelihood of cell death.
A model to account for the increased lifespan associated with reduced IGF1 signaling is related to the classic ‘rate of living’ hypothesis.
It is plausible that the process of aging is related to the number of cell divisions since conception (although other factors are also involved).
If the rate of cell turnover increases with higher levels of activation of IGF1R or related receptors, then at any fixed chronological age, there will have been more cell divisions in the ancestry of IGF-responsive cells of individuals with higher levels of receptor activation, compared with individuals with lower levels of activation.
By the measure of ‘number of cell divisions since conception’, at an arbitrary number of years since conception, the individual on the right has aged faster than the individual on the left.
If the process of aging proceeds at least in part as a function of the number of cell divisions since conception, rather than as a function of elapsed time since conception, the individual on the left would live longer.”
What this chart and explanation imply is that IGF increases cell division, so that the animal can mature at an early age and be able to survive. However, if there is an over secretion of Growth hormone, the IGF that is manufactured produces an early maturity, a larger animal and a quicker death, because the process of cell division has been accelerated.
THE ABOVE EXAMPLE OF HYPER SECRETION OF IGF IS GENETIC. BUT, THERE IS A DIETARY METHOD OF PRODUCING HIGHER LEVELS OF IGF.
Animals that ingest high levels of sugar containing FRUCTOSE also develop high levels of IGF. (These animals are only humans or their pets.) They too, age faster die younger and, coincidentally, develop more cancers.
WHY DOES FRUCTOSE RAISE IGF LEVELS?
In order to answer this question, we must return to Growth Hormone and its “Mechanism of Action.”
Growth hormone originates in the Pituitary Gland and then goes directly to the Liver.
In the liver, Growth Hormone stimulates the production of “Growth Factors.” It is the “Growth Factors” (like IGF) that produce the end result of causing cells to divide in the various organs of the body, such as, skin, muscles, bones, nervous system, etc. The “Growth Factors” can be stimulated to replicate and increase their numbers by other molecules other than Growth Hormone.
We know from observation, that if we force feed animals large quantities of nutrients the cells in certain tissues will multiply. The tissues that multiply are almost always involved with adipocytes or fat cells.
The French have a method of force feeding geese with corn and produce Fatty Liver from which they make a Pate called Pate Fois Gras. In America and Europe, mothers force feed their infants and produce infants with fatty livers at the ripe old age of two or three!
We can easily see that force feeding humans as they are growing, you can increase their size and the level of their IGF.
WHICH NUTRIENT STIMULATES THE PRODUCTION OF IGF?
All energy derived from nutrition by all animals come from the production of a molecule called Adenosine Tri-Phosphate, commonly referred to as ATP. The method in which ATP is generated is quite complex, and medical students spend months memorizing the various routes and molecular changes involved.
The entire process was elucidated by two Geniuses whose names are: Albert von Szent-Gyorgyi de Nagyrápolt of Hungary, and Hans Krebs of Germany. Both of these men won Nobel Prizes for their achievements. These men demonstrated how two atoms of carbon attached to a carrier molecule could create energy.
The process is diagrammed in a Cycle which was once known as the KREBS CYCLE but is now known as the CITRIC ACID CYCLE.
The important fact that they demonstrated was that energy must be extracted from a chain of TWO carbons. NOT ANY OTHER NUMBER BUT TWO!
When we study nutrition we see that all sources of energy, from sugars to fats to proteins must eventually form a TWO CARBON CHAIN.
Fructose is a sugar found in fruit and veggies in very small quantities.
Fructose has FIVE CARBONS. IT CANNOT BE DIVIDED BY TWO.
IT MUST GO TO THE LIVER, WHERE IT IS TURNED INTO FAT. Fructose must go to the liver and be taken apart and re-assembled to get its energy. BUT THE LIVER IS WHERE IGF IS LOCATED.
FRUCTOSE PRODUCES FAT
The metabolism of fructose produces fat in the form of triglycerides.
This production of fat stimulates the pituitary to produce Growth Hormone so that the fat can be stored in adipocytes or fat cells. The Growth Hormone molecules enter the liver and promote the production of IGF. IGF in turn promotes the mitosis or cell division of the adipocytes. Since it is an indiscriminate molecule, all cells are stimulated to divide.
The net result is aging!
IF YOU WANT TO STOP AGING , DO THE FOLLOWING:
- Do not eat anything containing fructose.
- Do not eat sucrose (sugar).
- Do not eat high fructose corn syrup.
- Eat small quantities of fruit, especially those high in fructose.
- No pastries!
- No cereals!
- Read the label. If it has sugar, do not eat!
- Watch your skin get better, your brain get better, your weight go down.
REMEMBER: no fructose, low insulin like growth factor. Low growth factor equals low cell turn-over.
It’s as simple as that!