WOMEN TAKING ACID BLOCKERS CAN HAVE A BROKEN HIP!
OMEPRAZOLE–MOST POPULAR PPI
WOMEN WHO TAKE ACID REFLUX PILLS CAN HAVE A BROKEN HIP!
Proton Pump Inhibitors Raise Hip Fracture Risk Over Time
Ricki Lewis, PhD
From Medscape and Wikipedia
See Dr. Pinna’s comments below…
COMMON PROTEIN PUMP INHIBITORS “PPI’s” ARE …
• Omeprazole (brand names: Losec, Prilosec, Zegerid, ocid, Lomac, Omepral, Omez)
• Lansoprazole (brand names: Prevacid, Zoton, Monolitum, Inhibitol, Levant, Lupizole)
• Dexlansoprazole (brand name: Kapidex, Dexilant)
• Esomeprazole (brand names: Nexium, Esotrex)
• Pantoprazole (brand names: Protonix, Somac, Pantoloc, Pantozol, Zurcal, Zentro, Pan, Controloc)
• Rabeprazole (brand names: Zechin, Rab
HERE ARE THE REAL FACTS FROM WIKIPEDIA…
Proton-pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production.
They are the most potent inhibitors of acid secretion available today.
may be a more effective means of treatment.[2] High dose or long-term use of PPIs carry a possible increased risk of bone fractures.[3]
NOT ONLY HIP FRACTURES…
The FDA is revising both the prescription and the over-the-counter (OTC) labels for PPIs to include the possible increased risk of fractures.
This new information is based upon FDA review of several long-term studies that reported an increased risk of fractures of the hip, wrist, and spine with PPI use.
Some studies found a greater risk for these fractures from higher doses of PPI or use for one year or more. Most studies evaluated individuals aged 50 or older and the increased risk of fractures was primarily in this group.
ALSO, THERE IS MORE…
CARDIAC ARRHYTHMIAS (IRREGULAR HEART BEATS)
In December 2010, a published report suggested a nearly four-fold increase in certain heart arrhythmias (focal atrial tachycardia and right ventricular outflow tract, RVOT tachycardia), the first time that PPIs have been reported to be proarrhythmic.[21]
The potential mechanism relates to pH, potassium and calcium changes in selected cardiac cells.
At this early date, and without additional confirmatory studies, there is no response from the FDA.
January 31, 2012 — A new study strengthens the association of long-term use of proton pump inhibitors (PPIs) with increased risk for hip fracture in postmenopausal women, particularly those who smoke.
PPIs can affect fracture risk by increasing secretion of gastrin, inhibiting calcium absorption, and altering osteoclast function.
Use of these drugs to treat indigestion increased when they became available over the counter in the United States in 2003.
In May 2010, the US Food and Drug Administration issued a warning about the possible link between extended PPI use and hip fracture and requested further information.
The new study, published online January 31 in the British Medical Journal, adds information from nearly 80,000 women to the body of data. Hamed Khalili, MD, from Massachusetts General Hospital, Boston, Massachusetts, and colleagues examined data from the prospective cohort Nurses’ Health Study, which provided information on lifestyle and dietary risk factors.
The study, which began in 1982, assesses participants by questionnaire every 2 years.
Use of PPIs increased nearly 3-fold from 2000 to 2008 among the 79,899 women in the study, from 6.7% to 18.9%. The researchers documented 893 hip fractures over 565,786 person-years of follow-up.
Absolute risk for hip fracture among the women who regularly used the drugs for at least 2 years was 2.02 events per 1000 person years compared with 1.51 events per 1000 person years among women who did not take the drugs.
The risk for hip fracture among women who used PPIs for 2 or more years was 35% higher .
The researchers conclude that “regular use of PPI was associated with increased risk of hip fracture among postmenopausal women, with the strongest risk observed in individuals with the longest duration of use or with a history of smoking.”
Dr. Pinna says…
Any biochemist looking at the chemical diagram
knows that we are dealing with a hormone here.
This group of medications has a very strong
effect on those cells that produce acid in the
stomach. It interferes with one of the basic
steps in the metabolism of all cells.
As a consequence, it not only stops acid
producing cells from producing acid, but it
stops bone producing cells from producing bone.
This is definitely not a drug to be taken
by anyone who has a “sour” stomach.
It should be prescribed by a trained physician.
Someone who is aware of the side effects, and can
determine whether the risk is worth the reward.
However, the FDA is a servant of the pharmaceutical
business and it want to help that industry make
exorbitant profits.
Here, we have an example of the American
government killing its citizens in the field of
medicine.
In every area of commerce, we see the same
thing. The American government favors special
interest groups at expense of the American
public.
At the moment, the private individual has
no recourse except to research every thing
in his life where money is involved.
Whenever you buy anything, there is danger.
And, making the situation worse, your
government and even the media are striving
to cheat you. It is a form of parasitism that
has no equal in nature.
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